Clinical Efficacy of Gyro Rotary Stereotactic Radiotherapy for Locally Advanced Non-small Cell Lung Cancer
Objective To observe the clinical efficacy of gyro rotary stereotactic radiotherapy(gyro knife)in the treatment of locally advanced non-small cell lung cancer(NSCLC).Methods A total of 60 patients with locally advanced NSCLC admitted to Shangrao Municipal Hospital from January 2021 to March 2023 were divided into control group(30 patients)and observation group(30 patients)according to random number table method.The control group was treated with conventional radiotherapy,and the observation group was treated with gyro knife radiotherapy.The clinical efficacy,tumor marker levels[squamous cell carcinoma antigen(SCC),carcinoembryonic antigen(CEA),neuron-specific enolase(NSE)],Karnofsky Performance Scale(KPS)score,Eastern Cooperative Oncology Group(ECOG)activity status score,acute radiation pneumonitis(ARP)occurrence,and adverse reactions were compared between the two groups.Results The disease control rate and objective remission rate of the observation group were higher than those of the control group(P＜0.05).After treatment,the levels of SCC,CEA and NSE in the two groups were lower than those before treatment,and the levels of SCC,CEA and NSE in the observation group were lower than those in the control group(P＜0.05).The KPS score of the two groups after treatment was higher than that before treatment,and the ECOG score was lower than that before treatment,whilethe KPS score of the observation group was higher than that of the control group,and the ECOG score was lower than that of the control group(P＜0.05).The incidence of ARP and adverse reactions in the observation group were lower than those in the control group(P＜0.05).Conclusion Gyro knife is effective in the treatment of locally advanced NSCLC,which can down-regulate the level of tumor markers,improve the body function,and reduce the risk of ARP and adverse reactions.
万方数据
维普
