Effects of Different Opioids on Delayed Nausea and Vomiting in Elderly Patients Undergoing Painless Enteroscopy
Objective To observe the effects of different opioids combined with etomidate-propofol(EP)mixture on delayed nausea and vomiting in elderly patients undergoing painless colonoscopy.Methods A total of 150 patients who underwent painless colonoscopy in our hospital from June 2022 to June 2023 were selected.They were randomly divided into dezocine group(group D),remifentanil group(group R)and oxycodone group(group O),with 50 patients in each group.Group D was intravenously injected with dezocine 0.04 mg/kg,group R was intravenously injected with remifentanil 0.4 μg/kg,group O was intravenously injected with oxycodone 0.04 mg/kg,and then slowly intravenous injection of EP mixture 0.15-0.2 ml/kg before colonoscopy.The MAP,HR and SpO2 were compared among the three groups before induction(T0),1 min after induction(T1),when the colonoscope passed through the colon liver area(T2),when the colonoscope withdrew from the body(T3),and after recovery(T4).The colonoscopy time,recovery time and total amount of EP mixture,and the occurrence of adverse reactions during operation and resuscitation room were observed.The patients were followed up for 1 and 3 days after surgery to see whether there was delayed nausea and vomiting.Results At T1,MAP,HR and SpO2 in the three groups were lower than those at T0,and the decrease of SpO2 in group R was greater than that in group D and group O(P＜0.05).The postoperative recovery time of group R was shorter than that of group D and group O,and the incidence of respiratory depression was higher than that of group D and group O(P＜0.05).There was no significant difference in the time of colonoscopy,the total amount of EP mixture,the incidence of intraoperative body movement,muscle tremor,dizziness,hypotension and bradycardia among the three groups(P＞0.05).The incidence of nausea and vomiting in group D and group O was higher than that in resuscitation room at 1 day after operation,and the incidence of nausea and vomiting in group R was lower than that in group D and group O at resuscitation room and 1 and 3 days after operation(P＜0.05).Conclusion Compared with dezocine and oxycodone,remifentanil combined with EP mixture for painless colonoscopy in elderly patients can make patients wake up faster,with less delayed nausea and vomiting after operation,but may cause transient respiratory depression.
DezocineRemifentanilOxycodoneColonoscopyElderlyNausea and vomiting
万方数据
维普
