Effect of Metoprolol Combined with Nicotinamide in the Treatment of Heart Failure Complicated with Arrhythmia and its Influence on Cardiac Function
Objective To study the clinical effect of metoprolol combined with nicotinamide in the treatment of heart failure(HF)complicated with arrhythmia and its effect on cardiac function.Methods A total of 60 patients with HF complicated with arrhythmia admitted to Guangfeng Hexiang Hospital from November 2020 to November 2022 were divided into control group(30 patients)and observation group(30 patients)by random number table method.The control group was treated with metoprolol,and the observation group was treated with nicotinamide on the basis of the control group.The clinical efficacy,cardiac function[left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)],arrhythmia attack(frequency and duration of attack),Memorial Symptom Assessment Scale-Heart Failure(MSAS-HF)score and adverse reactions were compared between the two groups.Results The total effective rate of the observation group(93.33％)was higher than that of the control group(76.67％)(P＜0.05).After treatment,LVEF in the two groups was higher than that before treatment,LVEDD and LVESD were lower than those before treatment,and LVEF in the observation group was higher than that in the control group,LVEDD and LVESD were lower than those in the control group(P＜0.05).After treatment,the frequency and duration of arrhythmia in the two groups were less than those before treatment,and the frequency and duration of arrhythmia in the observation group were less than those in the control group(P＜0.05).After treatment,the MSAS-HF score of the two groups was lower than that before treatment,and the MSAS-HF score of the observation group was lower than that of the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Metoprolol combined with nicotinamide is effective in the treatment of HF complicated with arrhythmia,which can improve the cardiac function of patients,reduce the frequency and time of arrhythmia,relieve the symptoms of heart failure,and do not increase the adverse drug reactions,with good safety.
Heart failureArrhythmiasMetoprololNicotinamideCardiac function
万方数据
维普
