Effect of Aspirin Combined with Clopidogrel on Coagulation Function and Hemorheology in Patients with Cerebral Infarction
Objective To observe the effect of aspirin combined with clopidogrel on coagulation function and hemorheology in patients with cerebral infarction.Methods A total of 60 patients with cerebral infarction diagnosed and treated in our hospital from April 2019 to April 2022 were selected as the research objects.They were divided into control group and observation group by random number table method,with 30 patients in each group.The control group was treated with aspirin,and the observation group was treated with clopidogrel on the basis of the control group.The clinical efficacy,coagulation function indexes[fibrinogen(FIB),prothrombin time(APTT),thrombin time(TT)],hemorheology indexes(whole blood viscosity,plasma viscosity,platelet aggregation rate),neurological deficit(NIHSS)score and clinical adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.33％,which was higher than 80.00％in the control group(P＜0.05).After treatment,FIB,APTT and TT in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P＜0.05).After treatment,the levels of whole blood viscosity,plasma viscosity and platelet aggregation rate in the two groups were lower than those in the control group,and those in the observation group were lower than those in the control group(P＜0.05).The NIHSS score of the two groups after treatment was lower than that before treatment,and that in the observation group was lower than that in the control group(P＜0.05).The incidence of adverse reactions in the observation group was 10.00％,which was compared with 6.67％in the control group,the difference was not statistically significant(P＞0.05).Conclusion Aspirin combined with clopidogrel in patients with cerebral infarction can improve the curative effect,improve the coagulation function and hemorheology indexes,reduce the neurological deficit score,promote the recovery of neurological function,and do not increase the adverse reactions,which has good application effectiveness.
万方数据
维普
