Objective To study the application value of precise positioning of lung ultrasound in sputum excretion of patients with pulmonary infection in intensive care unit.Methods A total of 78 patients with pulmonary infection admitted to ICU of Mianyang Central Hospital from June 2019 to June 2020 were selected and divided into control group(n=38)and experimental group(n=40)according to random number table.All patients received routine treatment and drug treatment.The control group was given routine nursing intervention,and the experimental group was supplemented with lung ultrasound-assisted sputum excretion on this basis.The sputum volume at 24 h after intervention,blood gas analysis index,inflammation index,clinical pulmonary infection score(CPIS),dyspnea scale score(mMRC),quality of life score(SF-36)and incidence of adverse events were compared between the two groups.Results The mMRC score of the experimental group was better than that of the control group(P<0.05).After 7 days of intervention,the sputum volume,CPIS score,carbon dioxide partial pressure(PaCO2),C-reactive protein and procalcitonin white blood cell count in the experimental group were lower than those in the control group,and SF-36 score,blood oxygen saturation(SaO2)and oxygen partial pressure(PaO2)were higher than those in the control group(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion Lung ultrasound-assisted sputum excretion nursing intervention can reduce the severity of dyspnea in ICU patients with pulmonary infection,reduce the inflammatory response,and improve their quality of life.