首页|腰椎融合术后邻近节段退变的发生因素及机制研究进展

腰椎融合术后邻近节段退变的发生因素及机制研究进展

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腰椎退变性疾病常引起慢性腰痛,腰椎减压及融合手术是治疗腰椎退变性疾病的主要有效方法,取得了显著的临床效果,但长期随访发现腰椎融合术后邻近节段病变发生率并不低,是导致二次手术的主要因素.腰椎融合术后邻近节段退变发生机制涉及生物力学、生理病理学、分子生物学等诸多学科和因素,是一个复杂的生理病理发展过程.本文就腰椎融合术后邻近节段病变的发生因素及机制进行综述,以期为临床外科制定手术方案提供理论参考,并为干预邻近节段病变提供理论依据.
Research Progress on Factors and Mechanism of Adjacent Segment Degeneration After Lumbar Fusion
Degenerative diseases of the lumbar spine often cause chronic low back pain.Lumbar decompression and fusion surgery is the main and effective method for the treatment of degenerative diseases of the lumbar spine,and has achieved remarkable clinical results.However,long-term follow-up found that the incidence of adjacent segment lesions after lumbar fusion was not low,which was the main factor leading to secondary surgery.The mechanism of adjacent segment degeneration after lumbar fusion involves many disciplines and factors such as biomechanics,physiopathology,molecular biology,etc.It is a complex physiological and pathological development process.This article reviews the factors and mechanisms of adjacent segment lesions after lumbar fusion,in order to provide a theoretical reference for clinical surgery to formulate surgical plans and provide a theoretical basis for the intervention of adjacent segment lesions.

Lumbar fusionAdjacent segment degenerationBiomechanics

欧裕福、肖增明

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中山大学附属第一医院广西医院骨科,广西 南宁 530022

广西医科大学研究生学院,广西 南宁 530021

腰椎融合 邻近节段退变 生物力学

广西自然科学基金

2020GXNS-FAA297217

2024

医学信息
国家卫生部信息化管理领导小组 中国电子学会中国医药信息学分会 陕西文博生物信息工程研究所

医学信息

影响因子:0.161
ISSN:1006-1959
年,卷(期):2024.37(10)
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