Research Progress on the Relationship Between Keap1-Nrf2-ARE Signaling Pathway and Diabetic Retinopathy
Diabetic retinopathy(DR)is the most common microvascular disease among diabetic complications,and it is the main cause of vision loss and even blindness in patients with diabetes mellitus(DM)in our country.In recent years,it has been found that oxidative stress is one of the pathogenesis of DR,and Kelch-like epichlorohydrin related protein-1(Keap1)-nuclear factor E2 related factor 2(Nrf2)-antioxidant response element(ARE)signaling pathway is the most important endogenous anti-oxidative stress pathway.Therefore,this article reviews the correlation between Keap1-Nrf2-ARE signaling pathway and oxidative stress and DR.
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