Meta-analysis of Risk Factors for Venous Thromboembolism in Patients with Brain Tumors
Objective To summarize the risk factors of venous thromboembolism in patients with brain tumors,so that clinical medical staff can identify the risk population of the disease as early as possible,and provide evidence-based medical basis for timely intervention.Methods The Cochrane Library,PubMed,EMbase,Web of Science,CINAHL,China National Knowledge Infrastructure(CNKI),Wanfang,and Weipu Biomedical Database were searched by computer to collect studies on venous thromboembolism in patients with brain tumors from the establishment of the database to July 31,2022.Data extraction and quality evaluation were performed on the literature,and Meta-analysis was performed using RevMan 5.3 soft ware.Results A total of 19 articles were included,and 33 risk factors were extracted.The results of Meta-analysis showed that advanced age[OR=1.44,95％CI(1.31,1.59),P＜0.000 01],advanced glioma[OR=1.74,95％CI(1.47,2.06),P＜0.000 01],motor dysfunction[OR=1.92,95％CI(1.17,3.16),P=0.01],body mass index[OR=1.13,95％CI(1.05,1.23),P=0.002],operation time＞4 h[OR=1.66,95％CI(1.46,1.89),P＜0.000 01],postoperative infection[OR=7.87,95％CI(3.95,15.66),P＜0.000 01],ventilator dependence[OR=2.76,95％CI(1.79,4.25),P＜0.000 01],D-dimer＞0.5 mg/L[OR=1.87,95％CI(1.43,2.45),P＜0.000 01],intraoperative blood loss[OR=5.49,95％CI(1.69,17.86),P=0.005]were risk factors for venous thromboembolism.Conclusion The existing evidence shows that the occurrence of venous thromboembolism in patients with brain tumors is related to many factors such as advanced age,advanced glioma,motor dysfunction,body mass index,operation time＞4 h,postoperative infection,ventilator dependence,D-dimer＞0.5 mg/L,and more bleeding.It is suggested that medical staff should identify relevant risk factors in clinical work and take preventive measures to reduce the risk of thrombosis.
Brain tuomorVenous thromboembolismRisk factorsEvidence medicine
国家科技期刊平台
NSTL
万方数据
