Clinical Value of Contrast-enhanced Ultrasound Combined with Contrast-enhanced CT in the Early Differential Diagnosis of Focal Nodular Hyperplasia and Small Hepatocellular Carcinoma
Objective To explore the value of contrast-enhanced ultrasound(CEUS)combined with contrast-enhanced CT(CECT)in the early differential diagnosis of focal nodular hyperplasia(FNH)and small hepatocellular carcinoma(SHCC).Methods From March 2000 to March 2023,50 patients with FNH and 32 patients with early SHCC admitted to the Jizhou District People's Hospital of Tianjin were selected as the research objects.CEUS and CECT were performed in turn.The CEUS parameters(initial regression time,peak halving time,descending branch slope)and CECT features(initial enhancement time,peak enhancement time,initial decline time)of FNH patients and SHCC patients were compared.The detection results of CEUS,CECT and their combined detection for the two diseases were statistically analyzed.The value of differential diagnosis(diagnostic accuracy,sensitivity and specificity)was analyzed.Results In CEUS examination,the initial regression time and peak halving time of FNH patients were later than those of SHCC patients,and descending branch slope was smaller than that of SHCC patients(P＜0.05).In CECT examination,there was no significant difference in the initial enhancement time between FNH patients and SHCC patients(P＞0.05),but the peak enhancement time and initial decline time in FNH patients were later than those in SHCC patients(P＜0.05).The detection rate of FNH and SHCC detected by CEUS combined with CECT was higher than that of single detection(P＜0.05).The diagnostic accuracy,sensitivity and specificity of CEUS combined with CECT for FNH and early SHCC were higher than those of single detection(P＜0.05).Conclusion CEUS and CECT have a definite role in the early differential diagnosis of FNH and SHCC,and the combined application of the two has better diagnostic value.
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