Clinical Efficacy of URL in the Treatment of Patients with Renal Calculi and its Effects on Renal Injury Factors,Coagulation Function and Oxidative Stress Products
Objective To study the clinical efficacy of URL in the treatment of patients with renal calculi and its effects on renal injury factors,coagulation function and oxidative stress products.Methods A total of 85 patients with renal calculi treated in Anfu County Hospital of Traditional Chinese Medicine from January to December 2022 were selected as the research objects.They were divided into control group(n=42)and observation group(n=43)by random number table method.The control group was treated with percutaneous nephrolithotomy,and the observation group was treated with flexible ureteroscopy(URL).The clinical efficacy,renal injury factors[creatinine(Scr),neutrophil gelatinase-associated lipocalin(NGAL),cysteine protease inhibitor C(CysC)],coagulation function indexes[coagulation reaction time(R value),blood clot formation time(K value),maximum width value(MA value)],oxidative stress products[superoxide dismutase(SOD),malondialdehyde(MDA)]and complication rate were compared between the two groups.Results The total effective rate of clinical treatment in the observation group was 93.01％,which was compared with 90.48％in the control group,the difference was not statistically significant(P＞0.05).NGAL,CysC and Scr in the two groups after operation were higher than those before operation,but NGAL in the observation group was lower than that in the control group,and CysC was higher than that in the control group(P＜0.05),while there was no significant difference in Scr index between the two groups(P＞0.05).The R value and K value of the two groups after operation were lower than those before operation,and the MA value was higher than that before operation,but the R value and K value of the observation group were higher than those of the control group(P＜0.05),while there was no significant difference in MA value between the two groups(P＞0.05).The SOD of the two groups after operation was lower than that before operation,and the MDA was higher than that before operation,but the SOD of the observation group was higher than that of the control group,and the MDA was lower than that of the control group(P＜0.05).Conclusion URL can achieve similar clinical efficacy as percutaneous nephrolithotomy in the treatment of renal calculi,and can reduce the effects on renal function,oxidative stress and coagulation function.It can be used as the first choice for clinical treatment of renal calculi.
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