Effect of Nalbuphine Hydrochloride and Ketorolac Tromethamine on Analgesic Effect and Hemodynamics in Patients with Craniocerebral Trauma Hemorrhage
Objective To study the effect of nalbuphine hydrochloride and ketorolac tromethamine on analgesia and hemodynamics in patients with craniocerebral trauma hemorrhage.Methods A total of 60 patients with craniocerebral trauma hemorrhage admitted to Guangxin District Hospital of Traditional Chinese Medicine of Shangrao City from June 2020 to June 2023 were selected as the research objects.According to the random number table method,they were divided into control group(30 patients)and observation group(30 patients).The control group was given ketorolac tromethamine for analgesia,while the observation group was given nalbuphine hydrochloride combined with ketorolac tromethamine for analgesia.The onset time of analgesia,Ricker Sedation-agitation Scale(SAS)score,analgesic effect[Visual Analogue Scale(VAS)score],hemodynamics[heart rate(HR),mean arterial pressure(MAP),respiratory rate(RR)]and adverse reactions were compared between the two groups.Results The onset time of analgesia in the observation group was shorter than that in the control group,and the SAS score was lower than that in the control group(P＜0.05).The VAS scores of the observation group at 30 min and 6 h after treatment were lower than those of the control group(P＜0.05).The HR,MAP and RR indexes of the two groups at 30 min after medication were lower than those before medication,and the HR,MAP and RR indexes of the observation group were lower than those of the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Nalbuphine hydrochloride combined with ketorolac tromethamine has a good analgesic effect in patients with craniocerebral trauma hemorrhage.It has a fast onset and good effect,can stabilize the hemodynamic level of patients,with good drug safety.
国家科技期刊平台
NSTL
万方数据
