Clinical Effect of Low-dose Methylprednisolone Sodium Succinate for Injection in the Treatment of Pediatric Sepsis and its Effect on Prognosis
Objective To study the clinical effect of low-dose methylprednisolone sodium succinate for injection(MSSI)in the treatment of pediatric sepsis and its effect on prognosis.Methods A total of 90 children with sepsis admitted to the Intensive Care Unit of Tianjin Children's Hospital from July 2020 to July 2023 were selected and divided into control group(45 children)and observation group(45 children)by random number table method.The control group received routine treatment,and the observation group was treated with low-dose MSSI on the basis of the control group.The clinical treatment effects[sequential organ failure assessment(SOFA)],hemodynamic indexes[heart rate(HR),mean arterial pressure(MAP)],serum inflammatory factors[procalcitonin(PCT)],prognosis(ICU hospitalization time,hospitalization time,shock incidence,28-day mortality)were compared between the two groups.Results After treatment,the SOFA scores of the two groups were lower than those before treatment,and the SOFA scores of the observation group were lower than those of the control group(P＜0.05).After treatment,HR in the two groups was less than that before treatment,MAP was higher than that before treatment,and HR in the observation group was less than that in the control group,MAP was higher than that in the control group(P＜0.05).After treatment,the PCT of the two groups were lower than those before treatment,and the PCT of the observation group were lower than those of the control group(P＜0.05).The ICU hospitalization time and hospitalization time of the observation group were shorter than those of the control group(P＜0.05),and the incidence of shock was lower than that of the control group(P＜0.05).The 28-day mortality of the two groups was 0.Conclusion Low-dose MSSI has a definite therapeutic effect on sepsis in children,which can alleviate the condition,restore the hemodynamic level of children,reduce the inflammation in the body,reduce the risk of shock,and accelerate the recovery of prognosis.
pediatric sepsisMethylprednisolone sodium succinate for injectionLow doseSerum inflammatory factorsHemodynamics
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