慢性阻塞性肺疾病合并肺部感染患者病原菌分布及影响因素研究
Study on Distribution and Influencing Factors of Pathogenic Bacteria in Patients with Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Infection
肖妹英1
作者信息
- 1. 泰和县中医院检验科,江西 泰和 343700
- 折叠
摘要
目的 研究慢性阻塞性肺疾病(COPD)合并肺部感染患者的病原菌分布及影响因素.方法 以2020年6月-2022年6月泰和县中医院收治的60例COPD患者为研究对象,其中COPD合并肺部感染患者共30例,设为感染组,另30例患者未发生肺部感染,设为未感染组,统计COPD合并肺部感染患者的病原菌分布情况,分析COPD合并肺部感染的影响因素.结果 30例COPD合并肺部感染患者共培养分离病原菌30株,其中革兰阴性菌最为常见,占76.67％,革兰阳性菌占20.00％,真菌占3.33％.单因素分析显示,感染组与未感染组年龄、住院时间、合并症种类、糖尿病史、吸烟史、抗生素使用种类、抗生素使用时长、是否机械通气比较,差异有统计学意义(P＜0.05).Logistic回归分析显示,年龄≥60岁、合并症种类≥2种、糖尿病史、抗生素使用时长≥15 d、机械通气是COPD合并肺部感染的独立危险因素.结论 COPD合并肺部感染患者的病原菌分布以革兰阴性菌为主,其年龄、合并症种类、糖尿病史、抗生素使用时长与机械通气是导致COPD合并肺部感染的独立危险因素.
Abstract
Objective To study the distribution and influencing factors of pathogenic bacteria in patients with chronic obstructive pulmonary disease(COPD)complicated with pulmonary infection.Methods From June 2020 to June 2022,60 patients with COPD admitted to Taihe County Traditional Chinese Medicine Hospital were selected as the research objects.Among them,30 patients with COPD complicated with pulmonary infection were set as the infection group,and the other 30 patients without pulmonary infection were set as the uninfected group.The distribution of pathogenic bacteria in patients with COPD complicated with pulmonary infection was counted,and the influencing factors of COPD complicated with pulmonary infection were analyzed.Results A total of 30 strains of pathogenic bacteria were isolated from 30 patients with COPD complicated with pulmonary infection.Among them,gram-negative bacteria were the most common,accounting for 76.67％,gram-positive bacteria accounted for 20.00％,and fungi accounted for 3.33％.Univariate analysis showed that there were statistically significant differences in age,length of hospital stay,types of complications,history of diabetes,history of smoking,types of antibiotics used,duration of antibiotics used,and mechanical ventilation between the infected group and the uninfected group(P＜0.05).Logistic regression analysis showed that age ≥ 60 years old,type of comorbidities ≥2,history of diabetes,duration of antibiotic use ≥ 15 d,and mechanical ventilation were independent risk factors for COPD complicated with pulmonary infection.Conclusion The distribution of pathogenic bacteria in patients with COPD complicated with pulmonary infection is mainly gram-negative bacteria.Age,type of complications,history of diabetes,duration of antibiotic use and mechanical ventilation are independent risk factors for COPD complicated with pulmonary infection.
关键词
慢性阻塞性肺疾病/肺部感染/病原菌/糖尿病/机械通气Key words
Chronic obstructive pulmonary disease/Pulmonary infection/Pathogenic bacteria/Diabetes mellitus/Mechanical ventilation引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据