临床药师参与肾衰竭患者抗感染药个体化给药的药学监护效果
Pharmaceutical Care Effect of Clinical Pharmacists Participating in Individualized Administration of Anti-infective Drugs in Patients with Renal Failure
万凌燕 1朱健 1范永荣1
作者信息
- 1. 铅山县中医院药剂科,江西铅山 334500
- 折叠
摘要
目的 研究临床药师参与肾衰竭患者抗感染药个体化给药的药学监护效果.方法 选取2022年1月-2023年1月我院接诊的80例肾衰竭患者为研究对象,运用随机数字表法分为观察组(n=40)和对照组(n=40).对照组由临床医生开具医嘱,观察组由临床医生开具医嘱,临床药师对患者实施药学服务,比较两组治疗效果、血压达标率、血红蛋白达标率、血清钙达标率、炎症因子水平、用药依从性及不良反应发生率.结果 观察组治疗总有效率为92.50％,高于对照组的82.50％(P＜0.05);观察组血压达标率、血红蛋白达标率及血清钙达标率均高于对照组(P＜0.05);两组干预后C反应蛋白(CRP)、白细胞介素(IL-6)、肿瘤坏死因子(TNF-α)水平均低于干预前,且观察组低于对照组(P＜0.05);观察组用药依从性良好率为97.50％,高于对照组的85.00％(P＜0.05);观察组不良反应发生率为5.00％,低于对照组的15.00％(P＜0.05).结论 临床药师参与肾衰竭患者抗感染药个体化给药的药学监护可提高给药合理性,降低不良反应发生率,提高治疗效果,提升血压、血红蛋白及血清钙达标率,并且可降低炎症因子水平.
Abstract
Objective To study the pharmaceutical care effect of clinical pharmacists participating in individualized administration of anti-infective drugs in patients with renal failure.Methods A total of 80 patients with renal failure who were admitted to our hospital from January 2022 to January 2023 were selected as the research objects.They were divided into observation group(n=40)and control group(n=40)by random number table method.The control group was given medical advice by clinicians,and the observation group was given medical advice by clinicians.Clinical pharmacists provided pharmaceutical services to patients.The treatment effect,blood pressure compliance rate,hemoglobin compliance rate,serum calcium compliance rate,inflammatory factor level,medication compliance and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 92.50％,which was higher than 82.50％in the control group(P＜0.05).The blood pressure compliance rate,hemoglobin compliance rate and serum calcium compliance rate in the observation group were higher than those in the control group(P＜0.05).After intervention,the levels of C-reactive protein(CRP),interleukin(IL-6)and tumor necrosis factor(TNF-α)in the two groups were lower than those before intervention,and those in the observation group were lower than those in the control group(P＜0.05).The good rate of medication compliance in the observation group was 97.50％,which was higher than 85.00％in the control group(P＜0.05).The incidence of adverse reactions in the observation group was 5.00％,which was lower than 15.00％in the control group(P＜0.05).Conclusion Clinical pharmacists participating in individualized administration of anti-infective drugs in patients with renal failure can promote the rationality of administration,reduce the incidence of adverse reactions,improve the therapeutic effect,improve the compliance rate of blood pressure,hemoglobin and serum calcium,and reduce the level of inflammatory factors.
关键词
临床药师/肾衰竭/抗感染药/个体化给药/药学监护Key words
Clinical pharmacists/Renal failure/Anti-infective drugs/Individualized administration/Pharmaceutical care引用本文复制引用
基金项目
上饶市科技计划项目(2023CZDX09)
出版年
2024
国家科技期刊平台
NSTL
万方数据