Pathogenesis of Gouty Arthritis Complicated with Hyperlipidemia and the Research Status of Treatment from the Spleen
Gouty arthritis(GA)is a metabolic disease in which purine metabolic disorders lead to urate deposition in joint synovium and other tissues,causing inflammation of joints and local tissues,and even leading to joint deformity and injury,and often complicated with hyperlipidemia,fatty liver,hypertension,and kidney disease.In addition,if the complications of GA are not well controlled,it will accelerate the progression of GA,and even involve the urinary and cardiovascular systems.Western medicine treatment of GA complicated with hyperlipidemia(HLP)is mainly based on taking atorvastatin calcium and fenofibrate,but long-term use will cause liver function damage.Relatively speaking,traditional Chinese medicine can act on the disease through the effective components,multiple pathways and multiple targets,and has high safety and small adverse reactions.Based on this,this paper discusses the research progress of spleen-invigorating prescriptions in improving insulin resistance,regulating intestinal flora,anti-oxidative stress and reducing inflammatory factors by consulting relevant literature,and further clarifies the pathogenesis of GA complicated with HLP,so as to provide theoretical reference and scientific basis for the clinical application of traditional Chinese medicine in the prevention and treatment of GA complicated with HLP.
Gouty arthritisHyperlipidemiaPathogenesisTreatment from the spleen
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