Study on Risk Factors of Death in Patients with Community-acquired Severe Pneumonia
Objective To explore the risk factors of death in community-acquired severe pneumonia,and to provide a theoretical basis for further optimizing the treatment of community-acquired severe pneumonia.Methods The data of patients with community-acquired severe pneumonia during hospitalization in the Affiliated Hospital of North Sichuan Medical College from January 2020 to December 2022 were retrospectively collected,and the included cases were divided into survival group and death group.Multivariate Logistic regression analysis was used to analyze the risk factors related to death,and the receiver operating characteristic curve(ROC curve)was drawn to analyze the predictive value of each index for community-acquired severe pneumonia.Results A total of 230 patients with community-acquired severe pneumonia were collected,including 78 patients(33.91％)in the death group and 152 patients(66.09％)in the survival group.There was no significant difference in age,gender,hypertension and chronic obstructive pulmonary disease between the two groups(P＞0.05).There were significant differences in C-reactive protein(CRP),troponin T(cTnT),procalcitonin(PCT),interleukin-6(IL-6),N-terminal pro-brain natriuretic peptide(NT-proBNP),alanine aminotransferase(ALT),prothrombin time(PT),lactic acid(LAC),D-dimer(D-Dimer)and ferritin(Ferritin)between the two groups(P＜0.05).The cut-off value of LAC,IL-6 and Ferritin combined to predict the risk of death was 0.174,the Youden index was 0.858,the sensitivity was 92.20％,the specificity was 93.60％,and the area under the ROC curve(AUC)was 0.968[95％CI(0.94,0.996)].Conclusion The increase of LAC,IL-6 and Ferritin is an independent risk factor for the death of community-acquired severe pneumonia.The combination of the four has a higher predictive value for the death of community-acquired severe pneumonia.
Community-acquired severe pneumoniaRisk factorsPredictive valueDeath
万方数据
维普
