Quantitative Analysis of the Changes of Retinal Vessels Before and After Anti-VEGF Drugs Combined with Laser Photocoagulation in the Treatment of Branch Retinal Vein Occlusion
Objective To analyze the changes of retinal blood vessels before and after anti-VEGF drugs combined with laser photocoagulation in the treatment of branch retinal vein occlusion.Methods A total of 70 patients with branch retinal vein occlusion diagnosed and treated in our hospital from March 2021 to January 2023 were selected as the observation group,and 70 healthy people who underwent physical examination in our hospital during the same period were selected as the control group.The observation group was treated with anti-VEGF drugs combined with laser.The retinal artery and vein vascular indexes[vascular wall thickness(WT),vascular wall cross-sectional area(WCSA),wall-to-cavity ratio(WLR)]were compared between the two groups.The retinal vein vascular indexes(WT,WCSA,WLR),best corrected visual acuity(BCVA),central retinal thickness(CRT)and the incidence of complications before and after treatment in the observation group were analyzed.Results There was no significant difference in WT,WCSA and WLR of retinal artery between the observation group and the control group(P＞0.05),while WT,WCSA and WLR of retinal vein in the observation group were higher than those in the control group(P＜0.05).After 3 months of treatment,WT,WCSA,WLR and CRT in the observation group were lower than those before treatment,and BCVA was higher than that before treatment(P＜0.05).There were no serious complications such as endophthalmitis,vitreous hemorrhage and retinal detachment in the observation group,and only mild subconjunctival hemorrhage occurred,which was absorbed by itself without intervention;patients with elevated intraocular pressure returned to normal after targeted intervention.Conclusion The diameter of retinal vessels in patients with branch retinal vein occlusion is narrow and the vascular wall is thickened.WT,WCSA and WLR can be used as important parameters to predict branch retinal vein occlusion in clinic.Anti-VEGF drugs combined with laser photocoagulation are effective in the treatment of branch retinal vein occlusion,which can promote the recovery of retinal vascular indexes.
万方数据
维普
