Anesthetic Effect of Propofol Anesthesia and Isoflurane Inhalation Anesthesia in Laparoscopic Cholecystectomy and its Effect on Cognitive Function
Objective To study the anesthetic effect of propofol anesthesia and isoflurane inhalation anesthesia in laparoscopic cholecystectomy(LC)and its effect on cognitive function of patients.Methods From January 2020 to March 2023,60 patients undergoing LC in Wanzai County People's Hospital were selected and divided into propofol group(30 patients)and isoflurane group(30 patients)according to the random number table method.The propofol group was given propofol pump injection anesthesia,and the isoflurane group was given isoflurane inhalation anesthesia.The anesthetic effect[alertness-sedation scale(OAAS)],hemodynamic level[mean arterial pressure(MAP)and heart rate(HR)],anesthesia recovery time(eye opening time,extubation time,orientation recovery time),postoperative cognitive function[Mini-mental State Examination Scale(MMSE)score,incidence of postoperative cognitive decline,incidence of postoperative cognitive dysfunction]were compared between the two groups.Results There was no significant difference in OAAS score between the two groups at different time points(P＞0.05).The MAP at 5 min after pneumoperitoneum and at the end of operation in the isoflurane group was higher than that in the propofol group,and the HR was lower than that in the propofol group(P＜0.05).The eye opening time,extubation time and orientation recovery time in the isoflurane group were shorter than those in the propofol group(P＜0.05).The postoperative MMSE score in the isoflurane group was lower than that in the propofol group,and the incidence of postoperative cognitive decline was higher than that in the propofol group(P＜0.05).Conclusion Both propofol anesthesia and isoflurane inhalation anesthesia can provide good anesthesia conditions for LC treatment.The anesthetic effects of the two are comparable,but the latter is more conducive to perioperative hemodynamic stability and faster recovery,but there is a certain risk of postoperative cognitive decline.
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