Analysis of Risk Factors for Acute Exacerbation of Chronic Obstructive Pulmonary Disease Complicated with Left Ventricular Systolic Dysfunction
Objective To investigate the risk factors of acute exacerbation of chronic obstructive pulmonary disease complicated with left ventricular systolic dysfunction.Methods A retrospective study of 84 patients with acute exacerbation of chronic obstructive pulmonary disease admitted to the Department of Respiratory Medicine of Wuhu First People's Hospital from April 2020 to April 2022.According to left ventricular ejection fraction(LVEF),they were divided into two groups:14 patients with LVEF＜50％were in the left ventricular systolic dysfunction group,and 70 patients with LVEF ≥50％were in the normal left ventricular systolic function group.The age,gender,smoking index,hospitalization time,arterial blood gas analysis(pH,PaO2,PaCO2,lactic acid),white blood cell count,C-reactive protein(CRP),procalcitonin(PCT),erythrocyte sedimentation rate(ESR),serum albumin,N-terminal pro-brain natriuretic peptide(NT-proBNP),and the percentage of forced expiratory volume in the first second(FEV1％pre)were compared between the two groups.Logistic regression was used to analyze the related independent risk factors.Results There were no significant differences in gender,age,smoking index,white blood cell count,C-reactive protein,procalcitonin,erythrocyte sedimentation rate,blood gas pH and hospitalization days between the two groups(P＞0.05).There were significant differences in PaO2,PCO2,lactic acid,NT-proBNP and albumin between the two groups(P＜0.05).Multivariate analysis by Logistic regression model showed that lactic acid was a risk factor for acute exacerbation of chronic obstructive pulmonary disease complicated with left ventricular systolic dysfunction,and serum albumin and FEV1％pre were protective factors for acute exacerbation of chronic obstructive pulmonary disease complicated with left ventricular systolic dysfunction.Conclusion For patients with low serum albumin,high lung function grade and high blood gas analysis lactic acid value,echocardiography should be performed as soon as possible to evaluate the cardiac function of patients,and corresponding treatment measures should be taken as soon as possible according to the EF value to improve the symptoms of patients.
万方数据
维普
