Study on the Mechanism of Suberect Spatholobus Stem in the Treatment of Gastric Cancer Based on Network Pharmacology
Objective To predict the potential mechanism of Suberect Spatholobus Stem in the treatment of gastric cancer by network pharmacology.Methods The active components and corresponding targets of Suberect Spatholobus Stem were obtained by TCMSP database,and the gastric cancer targets were collected by GeneCards,TTD and OMIM databases.The intersection targets of drugs and diseases were obtained by Wayne diagram,and the intersection target protein interaction network(PPI)was constructed by STRING database.The GO function and KEGG pathway enrichment analysis of the intersection targets were performed using the DAVID online tool.Results A total of 24 active components of Suberect Spatholobus Stem were obtained,corresponding to 104 targets,and a total of 1639 gastric cancer targets were collected.A total of 66 intersection targets of Suberect Spatholobus Stem-gastric cancer were obtained by Venn diagram.Key targets such as TP53,STAT3,AKT1,CASP3 and TNF were obtained by protein interaction network analysis.GO enrichment analysis obtained 489 biological process items,45 cell composition items and 89 molecular function items.KEGG pathway enrichment analysis obtained 159 signaling pathways,among which the pathways were mainly closely related to PIK3-Akt signaling pathway,IL-17 signaling pathway and HIF-1 signaling pathway.Conclusion Based on network pharmacology,it is preliminarily revealed that Suberect Spatholobus Stem anti-tumor may play a role by regulating key proteins such as TP53,STAT3,AKT1,CASP3 and TNF,and interfering with PIK3-Akt signaling pathway,IL-17 signaling pathway and HIF-1 signaling pathway.
Network pharmacologySuberect Spatholobus StemGastric cancer
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