Clinical Evaluation of Body Composition in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Objective To analyze the correlation between body composition and the risk of disease progression and the expression level of myogenic microRNAs(myomiRs)in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods The basic data and blood samples of 77 patients with AECOPD who were treated in the Second Affiliated Hospital of Fujian Medical University from February 2021 to December 2022 were selected.The body composition was measured by the body composition analyzer,and the content of myomiRs in plasma was detected by reverse transcription-polymerase chain reaction.Patients with two or more exacerbations per year were included in the high deterioration risk group(55 patients)and those with less than two exacerbations were included in the low deterioration risk group(22 patients).The differences in body composition between the two groups were compared to explore its relationship with disease progression and plasma myomiRs levels.Results The fat-free weight,fat-free body mass index and phase angle of the high deterioration risk group were lower than those of the low deterioration risk group,and the extracellular water ratio was higher than that of the low deterioration risk group,the difference were statistically significant(P＜0.05).The intracellular fluid and total body water in the high deterioration risk group were lower than those in the low deterioration risk group(P＜0.05).Logistic regression analysis showed that extracellular water ratio(OR=1.086,95％CI:1.010-1.168,P=0.026)and phase angle(OR=0.396,95％CI:0.164-0.957,P=0.040)were independently associated with the risk of disease progression.According to the receiver operating characteristic curve,the thresholds of extracellular water ratio and phase angle were 0.393％and 4.85°,respectively.The fat parameters(fat mass,fat index,body fat percentage and visceral fat area)of AECOPD patients were negatively correlated with the expression level of miR-206.Conclusion The extracellular water ratio and phase angle can be used to identify the deterioration risk of AECOPD patients.In addition,miR-206 is associated with fat parameters in patients with AECOPD,indicating that fat may be involved in the regulation of sarcopenia in patients.
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