Clinical Efficacy of Bismuth-containing Quadruple Therapy in the Treatment of Patients with Peptic Ulcer and its Effect on Ulcer Healing and Inflammatory Factors
Objective To study the clinical efficacy of bismuth-containing quadruple therapy in the treatment of peptic ulcer patients and its effect on ulcer healing and inflammatory factors.Methods A total of 60 patients with peptic ulcer admitted to the Department of Gastroenterology,Jiangxi Dexing Hospital from May 2020 to May 2023 were selected as the research objects.They were divided into triple group(30 patients)and quadruple group(30 patients)by random number table method.The triple group was treated with triple therapy(rabeprazole+amoxicillin+clarithromycin),and the quadruple group was treated with bismuth-containing quadruple therapy(colloidal bismuth pectin+rabeprazole+amoxicillin+clarithromycin).The clinical efficacy,ulcer healing(ulcer diameter,Lanza score of gastric mucosal injury),inflammatory factors[interleukin-2(IL-2),interleukin-6(IL-6)],adverse reactions,prognosis[peptic ulcer scale(QLICD-PU),gastric ulcer recurrence rate]were compared between the two groups.Results The total effective rate of treatment in the quadruple group was 96.67％,which was higher than 80.00％in the triple group(P＜0.05).After treatment,the ulcer diameter and Lanza score of gastric mucosal injury in the two groups were lower than those before treatment,and the ulcer diameter and Lanza score of gastric mucosal injury in the quadruple group were lower than those in the triple group(P＜0.05).After treatment,the levels of IL-2 and IL-6 in the two groups were lower than those before treatment,and the levels of IL-2 and IL-6 in the quadruple group were lower than those in the triple group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).The QLICD-PU score of the two groups after treatment was higher than that before treatment,and the QLICD-PU score of the quadruple group was higher than that of the triple group(P＜0.05).The recurrence rate of gastric ulcer in quadruple group was lower than that in triple group(P＜0.05).Conclusion Bismuth-containing quadruple therapy is effective in the treatment of peptic ulcer,which can promote ulcer healing,relieve inflammation in the body,improve the quality of life of prognosis,and has low recurrence rate and good drug safety.
Peptic ulcerBismuthagentQuadruple therapyUlcer healingAdverse reactionsQuality of life
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