Study on the Relationship Between Serum 5-hydroxytryptamine Level and Post-stroke Depression
Objective To investigate the relationship between serum 5-hydroxytryptamine(5-HT)level and post-stroke depression(PSD).Methods A total of 103 patients with acute ischemic stroke who were hospitalized in the Department of Neurology,Affiliated Hospital of Guilin Medical College from June 2021 to November 2022 were selected.According to the diagnostic criteria of depression in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders,combined with HAMD-17 and PHQ-9 for auxiliary diagnosis,the patients were divided into four groups:group A had obvious depression at baseline and follow-up,which met the PSD criteria;in group B,the baseline period met the PSD standard,and the depression recovered but did not meet the PSD standard at follow-up;in group C,the baseline period did not meet the PSD standard,and the depression during follow-up was in line with the PSD standard;group D had no depression at baseline and follow-up,which did not meet the PSD criteria.The clinical data of the four groups were compared,and the contribution of each factor to PSD was explored by binary Logistic regression analysis.ROC curve was used to analyze the diagnostic efficacy of 5-HT and NIHSS scores in predicting PSD.Results There were no significant differences in gender,age,HCY,LDL,fasting blood glucose and NIHSS scores among the four groups(P＞0.05),while there were significant differences in HAMD-17 baseline,PHQ-9-baseline,HAMD-17 follow-up,PHQ-9-follow-up and 5-HT levels among the four groups(P＜0.05).Binary Logistic regression analysis showed that NIHSS score and serum 5-HT level were independent predictors of PSD.ROC curve analysis showed that the predictive value of 5-HT combined with NIHSS score in the diagnosis of PSD was good(area under the curve was 0.817,95％confidence interval was 0.728-0.906,P＜0.05).Conclusion Serum 5-HT level is closely related to PSD and can accurately predict the occurrence of PSD.
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