Detection Value of Serum PG,G-17,IL-6,IL-23,IL-17 and TNF-α in Patients with Gastric Cancer
Objective To analyze the changes and combined detection value of serum pepsinogen(PG,PG I,PG Ⅱ),gastrin-17(G-17),interleukin(IL)-6,IL-23,IL-17 and tumor necrosis factor-α(TNF-α)in patients with gastric cancer.Methods A total of 122 patients with gastric cancer who were treated in our hospital from January 2022 to February 2023 were selected as the observation group,and 100 healthy subjects were selected as the control group for parallel control study.PGGⅠI,PGⅡ and G-17 were detected by double antibody sandwich immunoassay,and IL-6,IL-23,IL-17 and TNF-α were detected by enzyme-linked immunosorbent assay(ELISA).The levels of serum PG Ⅰ,PGⅡ,G-17,IL-6,IL-23,IL-17 and TNF-αwere compared between the two groups,and the differences of serum indexes between TNM stage Ⅰ-Ⅱ andstage Ⅲ-Ⅳ in the observation group were compared.The receiver operating characteristic curve(ROC curve)was used to analyze the predictive value of combined detection of serum indicators for gastric cancer progression(stage Ⅲ-Ⅳ).Results The serum PGⅠ in the observation group was lower than that in the control group,and the levels of serum PGⅡ,G-17,IL-6,IL-23,IL-17 and TNF-α were higher than those in the control group(P＜0.05).The levels of serum PGⅠ in patients with gastric cancer at TNM stage Ⅰ-Ⅱ were higher than those at TNM stage Ⅲ-Ⅳ,and the levels of serum PG Ⅱ,G-17,IL-6,IL-23,IL-17 and TNF-α were lower than those at TNM stage Ⅲ-Ⅳ(P＜0.05).In the single serum examination,the AUC of PGI in predicting the progression of gastric cancer was higher,which was 0.976,but the AUC of the combined detection of serum indexes in predicting the progression of gastric cancer(stage Ⅲ-Ⅳ)was higher,which was 0.984,the specificity was 98.90％,and the sensitivity was 92.60％.Conclusion The levels of PGⅡ,G-17,IL-6,IL-23,IL-17 and TNF-α in patients with gastric cancer are highly expressed,and the level of PGⅠ is low.There are significant differences in different TNM stages,which can predict the progression of gastric cancer,and the combined detection has the highest effect.
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