Observation on the Efficacy and Safety of Rifampicin Combined with Insulin in the Treatment of Pulmonary Tuberculosis Complicated with Diabetes Mellitus
Objective To observe the efficacy and safety of rifampicin combined with insulin in the treatment of pulmonary tuberculosis complicated with diabetes mellitus.Methods A total of 62 patients with pulmonary tuberculosis complicated with diabetes mellitus who were admitted to our hospital from January 2020 to June 2023 were selected as the research objects.They were divided into control group and observation group by random number table method,with 31 patients in each group.The control group was treated with oral hypoglycemic drugs(metformin,acarbose,dapagliflozin)combined with rifampicin,and the observation group was treated with insulin injection combined with rifampicin.The clinical efficacy,blood glucose indexes[fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c),2 h postprandial blood glucose(2 hPBG)],remission time of clinical symptoms(fever,cough,hemoptysis),time of blood glucose reaching the standard and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group(93.55％)was higher than that in the control group(83.87％)(P＜0.05).The levels of FBG,HbA1 c and 2 hPBG in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P＜0.05).The remission time of fever,cough,hemoptysis and the time of blood glucose reaching the standard in the observation group were lower than those in the control group(P＜0.05).The incidence of adverse reactions in the observation group(6.45％)was lower than that in the control group(19.35％)(P＜0.05).Conclusion Rifampicin combined with insulin in the treatment of pulmonary tuberculosis complicated with diabetes mellitus can improve the therapeutic effect,effectively improve the blood glucose index,shorten the time of blood glucose control and clinical symptom relief,and the incidence of adverse reactions is low.It is a feasible and effective treatment plan.
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