Effect of Propofol Combined with Remifentanil Target-controlled Infusion Anesthesia on Blood Pressure and Heart Rate in Patients with Acute Appendicitis Undergoing Laparoscopic Appendectomy
Objective To study the effect of propofol combined with remifentanil target-controlled infusion anesthesia on blood pressure and heart rate during laparoscopic appendectomy in patients with acute appendicitis.Methods A total of 66 patients with acute appendicitis who underwent laparoscopic appendectomy in our hospital from January 2021 to May 2023 were selected as the research objects.They were divided into control group and observation group by random number table method,with 33 patients in each group.The control group was treated with propofol combined with remifentanil intravenous anesthesia,and the observation group was treated with propofol combined with remifentanil target-controlled infusion anesthesia.The anesthesia indexes(onset time of anesthesia,spontaneous breathing time,awake time),mean blood pressure(MAP),heart rate(HR),pain score(VAS),sedation score(Ramsay)and incidence of adverse reactions were compared between the two groups.Results The onset time of anesthesia,spontaneous breathing time and awake time in the observation group were shorter than those in the control group(P＜0.05).The MAP and HR of the two groups after pneumoperitoneum were lower than those before anesthesia induction,but those of the observation group were higher than those of the control group(P＜0.05).The MAP and HR of the two groups at extubation were higher than those after pneumoperitoneum,but those of the observation group were lower than those of the control group(P＜0.05).The VAS score of the observation group at 8 h after operation was lower than that of the control group(P＜0.05).The Ramsay score of the observation group at extubation and 10 min after extubation was lower than that of the control group(P＜0.05).The incidence of adverse reactions in the observation group was 6.06％,which was lower than 15.15％in the control group(P＜0.05).Conclusion Propofol combined with remifentanil target-controlled infusion anesthesia is effective in laparoscopic appendectomy in patients with acute appendicitis,which can reduce the effect on blood pressure and heart rate,improve sedation score,reduce pain,shorten anesthesia recovery and onset time,and reduce the incidence of adverse reactions.
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