Efficacy of Salbutamol Combined with Ambroxol Hydrochloride in the Treatment of Chronic Obstructive Pulmonary Disease and its Effect on Pulmonary Function Indexes
Objective To study the clinical efficacy of salbutamol combined with ambroxol hydrochloride in the treatment of chronic obstructive pulmonary disease(COPD)and its effect on pulmonary function indexes.Methods From June 2020 to June 2023,62 patients with COPD admitted to the Hengfeng County Maternal and Child Health Hospital were divided into control group and observation group by random number table method,with 31 patients in each group.Both groups were given conventional treatment.On this basis,the control group was treated with salbutamol,while the observation group was treated with salbutamol combined with ambroxol hydrochloride.The clinical efficacy,pulmonary function[forced vital capacity(FVC),forced expiratory volume in one second(FEV1),one-second rate(FEV1/FVC)],symptom relief time(cough,sputum,chest tightness and shortness of breath),inflammatory indexes[C-reactive protein(CRP),interleukin-6(IL-6)]and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 96.77％,which was higher than 83.87％in the control group(P＜0.05).After treatment,the indexes of FVC,FEV1 and FEV1/FVC in the two groups were higher than those before treatment,and the indexes in the observation group were higher than those in the control group(P＜0.05).The symptoms relief time(cough,expectoration,dyspnea)in the observation group were shorter than those in the control group(P＜0.05).After treatment,the levels of CRP and IL-6 in the two groups were lower than those before treatment,and the levels of CRP and IL-6 in the observation group were lower than those in the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P＞0.05).Conclusion Salbutamol combined with ambroxol hydrochloride is effective in the treatment of COPD,which can improve lung function,accelerate symptom relief,down-regulate inflammatory indicators,and has high drug safety.
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