Correlation Analysis Between Serum Uric Acid/High Density Lipoprotein Cholesterol Ratio and Cardiac Structure and Function in Type 2 Diabetes Mellitus
Objective To analyze the correlation between serum uric acid/high-density lipoprotein cholesterol ratio(UHR)and cardiac structure and function in type 2 diabetes mellitus(T2DM).Methods A total of 408 patients with T2DM who were hospitalized in the Department of Endocrinology,Gansu Provincial People's Hospital from October 2021 to October 2022 were selected as the research objects.According to the ratio of serum uric acid/high-density lipoprotein cholesterol,the patients were divided into three groups:low UHR group(L-UHR,n=136),medium UHR group(M-UHR,n=136)and high UHR group(H-UHR,n=136).The basic information of patients,laboratory examination indicators,and cardiac ultrasound parameters were collected.Multivariate Logistic regression analysis was used to explore the risk factors of cardiac diastolic dysfunction in patients with T2DM.Pearson correlation analysis was used to analyze the correlation between UHR and other indicators.The receiver operating characteristic(ROC)curve of UHR combined with other indicators to predict cardiac diastolic dysfunction in T2DM patients was drawn to determine the optimal cut-off value.Results There were significant differences in gender,age,body mass index(BMI),glycosylated hemoglobin(HbA1c),visceral fat area(VFA),subcutaneous fat area(SFA),cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),albumin,creatinine(Scr),blood uric acid(SUA)and UHR among the three groups(P＜0.05).There were significant differences in left ventricular ejection fraction(LVEF),diastolic interventricular septal thickness(IVSd),diastolic left ventricular posterior wall thickness(LVPWd),left atrial diameter(LAd),diastolic left ventricular diameter(LVd),mitral annulus early and late diastolic blood flow peak velocity ratio(E/A),left ventricular mass(LVM)and left ventricular mass index(LVMI)among cardiac ultrasound parameters(P＜0.05).Multi variate Logistic regression analysis showed that after multivariate correction,UHR[OR=1.005,95％CI(1.001,1.010)],age[OR=1.070,95％CI(1.047,1.095)],TG[OR=1.149,95％CI(1.003,1.316)]were risk factors for cardiac diastolic dysfunction in T2DM patients(P＜0.05).Pearson correlation analysis showed that UHR was positively correlated with VFA,SFA,Scr,IVS,LVPW,LA and LV(P＜0.05),and negatively correlated with age,HbA1c,TC,LDL-C,estimated glomerular filtration rate(eGFR)and LVEF(P＜0.05).ROC curve showed that the optimal cut-off value of UHR combined with age and TG was 0.468,the sensitivity was 78.6％,the specificity was 57.60％,and the Youden index was 0.362;the area under the curve(AUC)of left ventricular diastolic dysfunction was UHR(0.631),age(0.627),TG(0.558),Logistic(P)(0.714),respectively.Conclusion With the increase of UHR value,the proportion of patients with left ventricular diastolic dysfunction gradually increases,and UHR can be used as an indicator to predict left ventricular diastolic dysfunction in patients with T2DM.
Serum uric acid/high-density lipoprotein cholesterolType 2 diabetes mellitusHeart structure and function
万方数据
维普
