Effect of Different Administration Methods of Insulin on Blood Glucose Control and Incidence of Hypoglycemia in Patients with Type 2 Diabetes Mellitus
Objective To study the effect of different insulin administration methods on blood glucose control and the incidence of hypoglycemia in patients with type 2 diabetes mellitus(T2DM).Methods Sixty patients with T2DM admitted to Yugan County People's Hospital from May 2020 to May 2023 were randomly divided into CSII group and MDI group,with 30 patients in each group.The CSII group was treated with continuous subcutaneous insulin infusion(CSII),and the MDI group was treated with multiple insulin injections(MDI).The blood glucose control effect(blood glucose compliance rate,blood glucose compliance time),blood glucose level[glycosylated hemoglobin(HbA1c),fasting blood glucose(FPG),2-h postprandial blood glucose(2hPBG)],blood glucose fluctuation[largest amplitude of glycemic excursion(LAGE),postprandial glucose excursions(PPGE)],islet function[fasting insulin(FINS),insulin resistance index(HOMA-IR)]and adverse reactions were compared between the two groups.Results There was no significant difference in blood glucose compliance rate between the two groups(P＞0.05),but the blood glucose compliance time of CSII group was shorter than that of MDI group(P＜0.05).The blood glucose levels(HbA1c,FPG,2hPBG)of the two groups after treatment were lower than those before treatment,and the blood glucose levels(HbA1c,FPG,2hPBG)of the CSII group after treatment were lower than those of the MDI group(P＜0.05).LAGE and PPGE in CSII group were lower than those in MDI group(P＜0.05).After treatment,FINS in the two groups was higher than that before treatment,HOMA-IR was lower than that before treatment,and FINS in the CSII group was higher than that in the MDI group,HOMA-IR was lower than that in the MDI group(P＜0.05).The incidence of adverse reactions in the CSII group was lower than that in the MDI group(P＜0.05).Conclusion Both CSII and MDI can control the blood glucose level of T2DM patients.Among them,CSII has shorter blood glucose compliance time and better hypoglycemic effect,which can reduce daytime blood glucose fluctuations,improve islet function and reduce the risk of adverse reactions.
Type 2 diabetes mellitusContinuous subcutaneous insulin infusionMultiple insulin injectionsBlood glucose control effectHypoglycemia
万方数据
维普
