Research Progress on the Relationship Between Apolipoprotein E and Different Stroke Subtypes
In the past 30 years,the crude mortality rate of stroke in China has increased rapidly and the rate of increase is higher than that of other countries in the world.Although there are continuous reports on how to control vascular risk factors,give anticoagulant drugs and surgical treatment of stroke,the disease still has a high risk of recurrence.In the coming years,China will face more and more stroke challenges.Studies have shown that apolipoprotein E(ApoE)is associated with the occurrence and development of atherosclerosis(AS)and cardiovascular and cerebrovascular diseases.Its gene polymorphism has an impact on different stroke subtypes.At present,there are few stroke treatment methods directly targeting ApoE.In view of this,this paper reviews the correlation and mechanism between ApoE and different stroke subtypes,and summarizes the new ideas of stroke treatment targeting ApoE in animal experiments,in order to provide reference for reducing the incidence,mortality and disease burden of stroke.
万方数据
维普
