Expression and Clinicopathological Significance of TRPC1 in Adenocarcinoma of Esophagogastric Junction
Objective To investigate the expression of TRPC1 in adenocarcinoma of esophagogastric junction(AEG)and its relationship with clinicopathological features and tumor immune microenvironment.Methods A total of 83 AEG specimens and 27 normal gastric mucosa tissues were selected from the Department of Pathology,Cancer Hospital of Shantou University Medical College from August 2017 to July 2022.The expression of TRPC1 in tumor tissues and normal gastric mucosa tissues of AEG patients was detected by immunohistochemistry.The difference of TRPC1 expression between tumor tissues and normal gastric mucosa tissues and its relationship with clinicopathological features and tumor immune microenvironment were analyzed.Results TRPC1 was expressed in different degrees in normal gastric mucosa tissues of AEG patients,and abnormal expression of TRPC1 was found in tumor tissues.The mean H score of TRPC1 expression in 83 patients was 84,including 50 cases(60.24％)with low expression of TRPC1 and 33 cases(39.76％)with high expression of TRPC1.The expression of TRPC1 was not correlated with gender,age,pathological T stage,lymph node metastasis,nerve invasion,vascular invasion,histological differentiation and immune index(P＞0.05).Spearman rank correlation test showed that TRPC1 expression was not correlated with CD8,CD163 and LAG-3(P＞0.05),but CD8 was negatively correlated with LAG-3(r=-0.226,P=0.040).Conclusion The abnormal expression of TRPC1 in adenocarcinoma of esophagogastric junction is not related to clinicopathological features and tumor infiltrating lymphocytes.
Adenocarcinoma of esophagogastric junctionTRPC1Tumor immune microenvironment
万方数据
维普
