Effect of Gestational Diabetes Mellitus on Early Neonatal Respiratory Diseases
Objective To investigate the effect of maternal gestational diabetes mellitus(GDM)on early neonatal respiratory diseases.Methods A total of 5702 singleton and live birth newborns delivered in the Department of Obstetrics,Qinzhou Maternal and Child Health Care Hospital from January to December 2018 were selected as the research objects.According to whether the mother had GDM,the newborns were divided into GDM group(n=830)and non-GDM group(n=4872).According to whether the maternal blood glucose during pregnancy was within the control target value,the GDM group was divided into the blood glucose control target group(n=755)and the blood glucose control non-target group(n=75).The incidence of neonatal respiratory distress syndrome(RDS),neonatal wet lung,infectious pneumonia,pneumothorax,meconium aspiration syndrome and mechanical ventilation requirements were compared among the groups.Results The incidences of premature delivery(10.60％vs.7.02％),macrosomia(5.42％vs.2.36％)and cesarean section(42.41％vs.34.56％)in GDM group were higher than that in non-GDM group,and the difference were statistically significant(P＜0.05).The incidence of wet lung in GDM group was higher than that in non-GDM group(1.20％vs.0.39％,P＜0.05.The incidences of respiratory diseases(17.33％vs.2.91％),RDS(5.33％vs.1.32％),wet lung(8.00％vs.0.53％)and the need for respiratory support(8.0％vs.1.2％)in the blood glucose control target group were higher than those in the blood glucose control non-target group,and the differences were statistically significant(P＜0.05).The substandard blood glucose control of GDM mothers was a risk factor for respiratory diseases(OR=6.986,95％CL3.357-14.540,P=0.000)and neonatal wet lung(OR=3.593,95％CL 1.990-6.488,P=0.000).Conclusion The incidence of neonatal respiratory diseases,RDS,wet lung and the proportion of respiratory support are increased in GDM mothers with poor blood glucose control during pregnancy.The substandard blood glucose control of GDM mothers is a risk factor for respiratory diseases and neonatal wet lung.We should pay attention to the perinatal health care of GDM mothers,so that their blood glucose during pregnancy can be well controlled to improve the clinical prognosis of newborns.
万方数据
维普
