Objective To investigate the correlation between serum leptin,adiponectin,retinoic acid receptor-reactive protein 2 levels and lung function in obese children with asthma.Methods A total of 70 children with asthma who were treated in our hospital from June 2021 to June 2022 were selected as the research objects.According to the body mass index of the children,they were divided into normal group(n=35)and obese group(n=35).The expression levels of serum leptin,adiponectin and retinoic acid receptor-reactive protein 2 were compared between the two groups.The percentage of forced vital capacity(FVC)in the predicted value(FVC％)and the percentage of forced expiratory volume in the first second(FEV1)in the predicted value(FEV1％)were detected by pulmonary function instrument.The correlation between serum leptin,adiponectin,retinoic acid receptor-reactive protein 2 and lung function in obese children with asthma was analyzed.Results The expression levels of FVC％,FEV1％and adiponectin in the obese group were lower than those in the normal group,and the levels of serum leptin and retinoic acid receptor-reactive protein 2 were higher than those in the normal group,the differences were statistically significant(P＜0.05).The positive expression level of adiponectin was positively correlated with lung function,while the expression levels of leptin and retinoic acid receptor-reactive protein 2 were negatively correlated with lung function(P＜0.05).Conclusion The levels of serum leptin,adiponectin and retinoic acid receptor-reactive protein 2 in obese children with asthma are highly correlated with the lung function of obese children with asthma,which can be used as an effective index to predict the lung function of obese children with asthma.
Serum leptinAdiponectinRetinoic acid receptor-reactive protein 2Lung functionObese asthma
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