Effect of Empagliflozin on Blood Glucose Level and Insulin Resistance in Patients with Type 2 Diabetes Mellitus
Objective To study the effect of empagliflozin on blood glucose level and insulin resistance in patients with type 2 diabetes mellitus.Methods A total of 72 patients with type 2 diabetes ellitus who were diagnosed and treated in our hospital from April 2020 to April 2023 were selected as the research objects.They were divided into control group(n=36)and observation group(n=36)by random number table method.The control group was treated with metformin hydrochloride tablets,and the observation group was treated with empagliflozin on the basis of the control group.The clinical efficacy,blood glucose indexes[fasting blood glucose(FPG),2-h postprandial blood glucose(2hPG),glycosylated hemoglobin(HbA1c)],insulin resistance index(HOMA-IR),fasting insulin(FIns),blood lipid indexes[total cholesterol(TC),triglyceride(TG)]and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 94.44％,which was higher than 83.33％in the control group(P＜0.05).FPG,2hPG and HbA1c in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P＜0.05).HOMA-IR in the two groups was lower than that before treatment,FIns was higher than that before treatment,and HOMA-IR in the observation group was lower than that in the control group,FIns was higher than that in the control group(P＜0.05).TC and TG in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P＜0.05).The incidence of adverse reactions in the observation group was 5.56％,which was lower than 13.89％in the control group(P＜0.05).Conclusion Empagliflozin is effective in the treatment of type 2 diabetes mellitus,which can promote the control of blood glucose level,reduce insulin resistance,improve blood lipid index level,and reduce the incidence of adverse reactions.It is an effective and safe drug,which is worthy of clinical application.
万方数据
维普
