Clinical Efficacy of Niaoduqing Granules Combined with Coated Aldehyde Oxystarch in the Treatment of Chronic Renal Failure and its Effect on Oxidative Stress Indexes
Objective To explore the clinical efficacy of Niaoduqing granules combined with coated aldehyde oxystarch in the treatment of chronic renal failure(CRF)and its effect on oxidative stress indexes.Methods A total of 62 patients with CRF admitted to Jishui County People's Hospital from April 2021 to May 2023 were enrolled in the study.They were divided into control group(31 patients)and observation group(31 patients)by random number table method.The control group was given oral treatment of coated aldehyde oxystarch,and the observation group was treated with Niaoduqing granules on the basis of the control group.The clinical efficacy,TCM symptom scores(nausea and vomiting,facial edema,lassitude),renal function indexes[serum creatinine(Cr),urea nitrogen(BUN),urinary microalbumin(ALB)],oxidative stress indexes[C-reactive protein(CRP),superoxide dismutase(SOD),malondialdehyde(MDA)]were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group(P＜0.05).After treatment,the scores of nausea and vomiting,facial edema and fatigue in the two groups were lower than those before treatment,and the scores of nausea and vomiting,facial edema and fatigue in the observation group were lower than those in the control group(P＜0.05).After treatment,Cr,BUN and ALB in the two groups were lower than those before treatment,and Cr,BUN and ALB in the observation group were lower than those in the control group(P＜0.05).After treatment,CRP and MDA in the two groups were lower than those before treatment,SOD was higher than that before treatment,and CRP and MDA in the observation group were lower than those in the control group,SOD was higher than that in the control group(P＜0.05).Conclusion The curative effect of Niaoduqing granules combined with coated aldehyde oxystarch in the treatment of CRF is positive,which can effectively alleviate the symptoms of patients,improve their renal function and reduce the oxidative stress state of the body.
Chronic renal failureNiaoduqing granulesCoated aldehyde oxystarchOxidative stressRenal function
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维普
