Chemotherapy Effect of Pemetrexed Combined with Cisplatin in Advanced Non-small Cell Lung Cancer and its Effect on Serum Tumor Markers
Objective To study the chemotherapy effect of pemetrexed combined with cisplatin in advanced non-small cell lung cancer(NSCLC)and its effect on serum tumor markers.Methods A total of 70 patients with NSCLC admitted to Wanzai County People's Hospital from January 2016 to December 2021 were divided into PC group(35 patients)and GC group(35 patients)by random number table method.The PC group was treated with pemetrexed combined with cisplatin chemotherapy,and the CC group was treated with gemcitabine combined with cisplatin chemotherapy.The short-term efficacy,serum tumor markers[carcinoembryonic antigen(CEA),cytokeratin 19 fragment(CYFRA-211),neuron-specific enolase(NSE)],toxic and side effects,long-term efficacy(local recurrence rate,distant metastasis rate,mortality,progression-free survival),quality of life[quality of life scale for lung cancer patients(FACT-L)]were compared between the two groups.Results There was no significant difference in objective remission rate and disease control rate between the two groups(P＞0.05).The levels of CEA,CYFRA-211 and NSE in the two groups after treatment were lower than those before treatment,and the levels of CEA,CYFRA-211 and NSE in the PC group were lower than those in the GC group(P＜0.05).The incidence of side effects in PC group was lower than that in CC group(P＜0.05).There was no significant difference in local recurrence rate,distant metastasis rate and mortality between the two groups at 6 months after treatment(P＞0.05),but the progression-free survival of PC group was longer than that of GC group(P＜0.05).The FACT-L score of the two groups at 6 months after treatment was higher than that before treatment,and the FACT-L score of the PC group was higher than that of the GC group(P＜0.05).Conclusion Pemetrexed combined with cisplatin is effective in the treatment of advanced NSCLC,which can reduce the level of serum tumor markers,reduce the toxic and side effects of drugs,prolong the progression-free survival of patients,and improve the quality of life of prognosis.
Non-small cell lung cancerChemotherapyPemetrexedCisplatinSerum tumor markersQuality of Life
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