Clinical Efficacy and Adverse Reactions of Sodium Valproate Combined with Clonazepam in the Treatment of Refractory Epilepsy
Objective To study the clinical efficacy and adverse reactions of sodium valproate combined with clonazepam in the treatment of refractory epilepsy.Methods A total of 60 patients with refractory epilepsy admitted to the Department of Psychiatry,Shanggao County Hospital of Traditional Chinese Medicine from January 2021 to January 2023 were randomly divided into control group(30 patients)and observation group(30 patients).The control group was treated with sodium valproate,and the observation group was treated with sodium valproate combined with clonazepam.The efficacy of epilepsy control,improvement of EEG discharge,National Hospital Epilepsy Severity Scale(NHS3),Quality of Life Scale for Epilepsy Patients(QOLIE-31)score and adverse reactions were compared between the two groups.Results The effective rate of control in the observation group was higher than that in the control group(P＜0.05).The improvement rate of discharge in the observation group was higher than that in the control group(P＜0.05).After treatment,the NHS3 score of the two groups was lower than that before treatment,the QOLIE-31 score was higher than that before treatment,and the NHS3 score of the observation group was lower than that of the control group,the QOLIE-31 score was higher than that of the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Sodium valproate combined with clonazepam has a definite effect on refractory epilepsy,which can improve the control effect of epilepsy and reduce epileptic discharge.Meanwhile,it is helpful to improve the severity and quality of life of patients,and the safety of medication is high.
Refractory epilepsySodium valproateClonazepamEpileptic dischargeQuality of Life
万方数据
维普
