Effect of Atorvastatin Calcium Tablets Combined with Aspirin on Blood Lipid and Hemorheology in Patients with Cerebral Arteriosclerosis
Objective To observe the effect of atorvastatin calcium tablets combined with aspirin on blood lipid and hemorheology in patients with cerebral arteriosclerosis.Methods A total of 69 patients with cerebral arteriosclerosis admitted to Wan'an County People's Hospital from December 2020 to January 2023 were selected as the research objects.They were divided into control group(n=34)and observation group(n=35)by random number table method.The control group was treated with aspirin,and the observation group was treated with atorvastatin calcium tablets on the basis of the control group.The clinical efficacy,blood lipid indexes[cholesterol(TC),high density lipoprotein cholesterol(HDL-C),triglyceride(TG)],hemodynamic indexes[cerebral vascular pulsation index(PI),vascular resistance index(RI),systolic blood flow velocity(Vs),diastolic blood flow velocity(Vd)]and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 94.29%,which was higher than 85.29%in the control group(P<0.05).After treatment,TC and TG in the two groups were lower than those before treatment,HDL-C was higher than that before treatment,and TC and TG in the observation group were lower than those in the control group,HDL-C was higher than that in the control group(P<0.05).After treatment,PI and RI in the two groups were lower than those before treatment,Vs and Vd were higher than those before treatment,and PI and RI in the observation group were lower than those in the control group,Vs and Vd were higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion Atorvastatin calcium tablets combined with aspirin have a good effect in the treatment of cerebral arteriosclerosis,which can effectively improve the blood lipid index and hemorheology level of patients without increasing the incidence of adverse reactions.It has ideal application effectiveness and safety.
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