Clinical Efficacy of Cefoperazone Sodium and Sulbactam Sodium in the Treatment of Acute Exacerbation of Chronic Obstructive Pneumonia and its Effect on Respiratory Function
Objective To observe the clinical efficacy of cefoperazone sodium and sulbactam sodium in the treatment of acute exacerbation of chronic obstructive pneumonia disease and its effect on respiratory function.Methods A total of 72 patients with acute exacerbation of chronic obstructive pneumonia disease diagnosed and treated in our hospital from April 2022 to April 2023 were selected as the research objects.They were divided into control group and observation group by random number table method,with 36 patients in each group.The control group was treated with ceftazidime,and the observation group was treated with cefoperazone sodium and sulbactam sodium.The clinical efficacy,respiratory function indexes[blood oxygen saturation(SaO2),oxygen partial pressure(PaO2),carbon dioxide partial pressure(PaCO2)],clinical symptoms(pulmonary rales,cough,shortness of breath)scores and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group(94.44%)was higher than that in the control group(80.56%)(P<0.05).SaO2 and PaO2 in the two groups were higher than those before treatment,PaCO2 was lower than that before treatment,and SaO2 and PaO2 in the observation group were higher than those in the control group,PaCO2 was lower than that in the control group(P<0.05).The scores of pulmonary rales,cough and shortness of breath in the observation group were lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion Cefoperazone sodium and sulbactam sodium is effective in the treatment of acute exacerbation of chronic obstructive pneumonia,which can significantly improve the respiratory function of patients,reduce clinical symptoms,and the safety of treatment is relatively high.It is worthy of clinical application.
Cefoperazone sodium and sulbactam sodiumAcute exacerbation of chronic obstructive pulmonary diseaseRespiratory function
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