Clinical Effect of Ambroxol Hydrochloride and Clenbuterol Hydrochloride Oral Solution Combined with Chest Wall Oscillation Instrument and Ipratropium Bromide Aerosol Inhalation in the Treatment of Pneumonia in Children
Objective To study the clinical effect of ambroxol hydrochloride and clenbuterol hydrochloride oral solution combined with chest wall oscillation instrument and ipratropium bromide atomization inhalation in the treatment of children with pneumonia.Methods From July 2022 to June 2023,60 children with pneumonia admitted to the Department of Pediatrics,Xinfeng County People's Hospital were selected and divided into control group(30 children)and treatment group(30 children)by random number table method.The control group was treated with ambroxol oral liquid and in vitro oscillation sputum elimination instrument,and the treatment group was treated with ipratropium bromide aerosol inhalation on the basis of the control group.The sputum discharge time,disappearance time of lung moist rales,remission of dyspnea(respiratory rate,proportion of three concave signs),pulmonary ventilation[blood oxygen saturation(SaO2),blood oxygen partial pressure(PaO2),blood carbon dioxide partial pressure(PaCO2)],complications(pulmonary consolidation,atelectasis,hypoxemia),ventilator utilization rate and hospitalization time were compared between the two groups.Results The sputum discharge time and lung moist rale disappearance time in the treatment group were shorter than those in the control group(P<0.05).After treatment,the respiratory rate and the proportion of three-concave sign in the two groups were lower than those before treatment,and the respiratory rate and the proportion of three-concave sign in the treatment group were lower than those in the control group(P<0.05).After treatment,SaO2 and PaO2 in the two groups were higher than those before treatment,PaCO2 was lower than that before treatment,and SaO2 and PaO2 in the treatment group were higher than those in the control group,PaCO2 was lower than that in the control group(P<0.05).The incidence of pulmonary consolidation,atelectasis and hypoxemia in the treatment group was lower than that in the control group(P<0.05).The ventilator utilization rate in the treatment group was lower than that in the control group,and the hospitalization time was shorter than that in the control group(P<0.05).Conclusion The effect of ambroxol hydrochloride and clenbuterol hydrochloride oral solution combined with chest wall oscillation instrument and ipratropium bromide atomization inhalation in the treatment of children with pneumonia is definite,which can accelerate sputum discharge,shorten the disappearance time of lung wet rales in children,and is beneficial to the relief of dyspnea symptoms in children.Meanwhile,it can improve the pulmonary ventilation function,reduce the risk of pulmonary consolidation,atelectasis and hypoxemia,reduce the utilization rate of ventilator and shorten the hospitalization time.
Pneumonia in childrenAmbroxol hydrochloride and clenbuterol hydrochlorideChest wall oscillation instrumentIpratropium bromideRespiratoryrateThree-concave sign
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