Effect of Autologous Platelet-rich Plasma Intrauterine Perfusion on Endometrial Thickness,Hemodynamics and Ovulation Rate in Patients with Thin Uterus
Objective To study the effect of intrauterine infusion of autologous platelet-rich plasma on endometrial thickness,hemodynamics and ovulation rate in patients with thin uterus.Methods A total of 60 patients with thin endometrium who underwent frozen-thawed embryo transfer in our hospital from April 2022 to April 2023 were selected as the research objects. They were divided into control group and observation group by random number table method,with 30 patients in each group. The control group was treated with normal saline intrauterine perfusion,and the observation group was treated with platelet-rich plasma (PRP) intrauterine perfusion. The endometrial thickness,hemodynamics[vascular resistance index (RI),pulsatility index (PI),end-systolic/end-diastolic blood flow velocity ratio (S/D)],dominant follicle development rate,ovulation rate and incidence of adverse reactions were compared between the two groups.Results The endometrial thickness of the observation group was greater than that of the control group (P<0.05). RI,PI and S/D in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group (P<0.05). The dominant follicle development rate and ovulation rate in the observation group were higher than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the observation group (10.00％) and the control group (6.67％) (P>0.05).Conclusion Autologous platelet-rich plasma intrauterine perfusion has a positive effect on endometrial thickness,hemodynamics and ovulation rate in patients with thin uterus. Meanwhile,it can increase endometrial thickness,improve ovulation rate and uterine hemodynamics,and has no significant incidence of adverse reactions. It is a feasible and safe treatment method.
万方数据
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