摘要
目的 分析肺力咳合剂+阿莫西林克拉维酸钾在小儿急性支气管炎中的疗效及对炎症细胞因子的影响.方法 按照随机数字表法将2020年7月-2023年2月我院收治的62例小儿急性支气管炎患儿分为对照组和研究组,每组31例.对照组仅接受肺力咳合剂治疗,研究组接受肺力咳合剂+阿莫西林克拉维酸钾治疗.比较两组临床疗效、症状(发热、咳嗽、咳痰、肺部湿啰音)消失时间、炎症因子指标[C反应蛋白(CRP)、降钙素原(PCT)、白介素6(IL-6)、肿瘤坏死因子α(TNF-α)]、肺功能指标[用力肺活量(FVC)、呼气流量峰值(PEF)、第一秒用力呼气量(FEV1)].结果 研究组治疗总有效率(96.77％)高于对照组(77.42％)(P<0.05);研究组发热、咳嗽、咳痰、肺部湿啰音消失时间较对照组缩短(P<0.05);两组治疗后CRP、PCT、TNF-α、IL-6水平较治疗前降低,且研究组CRP、PCT、TNF-α、IL-6水平较对照组降低(P<0.05);两组治疗后FEV1、FVC、PEF水平较治疗前升高,且研究组FEV1、FVC、PEF水平较对照组升高(P<0.05).结论 肺力咳合剂+阿莫西林克拉维酸钾治疗小儿急性支气管炎的效果确切,有利于快速消除患儿临床症状,改善患者肺功能以及炎症因子水平.
Abstract
Objective To evaluate therapeutic impact of a combination therapy using Feilike mixture and amoxicillin-clavulanate on pediatric patients with acute bronchitis,along with its influence on inflammatory markers. Methods Using a random number table,62 children diagnosed with acute bronchitis,who were admitted to our facility between July 2020 and February 2023,were categorized into two groups:a control group and a study group,with 31 children in each group. The control group received treatment solely with Feilike mixture,whereas the study group was administered a regimen that included both Feilike mixture and amoxicillin-clavulanate. The following parameters were compared between the two groups:clinical outcomes,duration until the resolution of symptoms (such as fever,cough,sputum production,and lung crackles),levels of inflammatory biomarkers[C-reactive protein (CRP),procalcitonin (PCT),interleukin-6 (IL-6),and tumor necrosis factor-α (TNF-α)],and pulmonary function metrics[forced vital capacity (FVC),peak expiratory flow (PEF),and forced expiratory volume in one second (FEV1)].Results The study group demonstrated a superior overall efficacy rate of 96.77％,which was higher than the 77.42％ observed in the control group (P<0.05). The study group also exhibited a faster resolution of symptoms,including fever,cough,lung moist rales,and sputum production,compared to the control group (P<0.05). After treatment,both groups showed a reduction in CRP,PCT,TNF-α,and IL-6 levels,but the study group had a more pronounced decrease (P<0.05). Similarly,while both groups experienced an improvement in FEV1,FVC,and PEF,the study group had a greater enhancement (P<0.05).Conclusion The combination of Feilike mixture and amoxicillin with clavulanate potassium for treating acute bronchitis in children yielded excellent results,markedly lowering serum inflammatory cytokine levels.
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