Clinical Effect of Feilike Mixture+Amoxicillin and Clavulanate Potassium in the Treatment of Acute Bronchitis in Children
Objective To evaluate therapeutic impact of a combination therapy using Feilike mixture and amoxicillin-clavulanate on pediatric patients with acute bronchitis,along with its influence on inflammatory markers. Methods Using a random number table,62 children diagnosed with acute bronchitis,who were admitted to our facility between July 2020 and February 2023,were categorized into two groups:a control group and a study group,with 31 children in each group. The control group received treatment solely with Feilike mixture,whereas the study group was administered a regimen that included both Feilike mixture and amoxicillin-clavulanate. The following parameters were compared between the two groups:clinical outcomes,duration until the resolution of symptoms (such as fever,cough,sputum production,and lung crackles),levels of inflammatory biomarkers[C-reactive protein (CRP),procalcitonin (PCT),interleukin-6 (IL-6),and tumor necrosis factor-α (TNF-α)],and pulmonary function metrics[forced vital capacity (FVC),peak expiratory flow (PEF),and forced expiratory volume in one second (FEV1)].Results The study group demonstrated a superior overall efficacy rate of 96.77％,which was higher than the 77.42％ observed in the control group (P<0.05). The study group also exhibited a faster resolution of symptoms,including fever,cough,lung moist rales,and sputum production,compared to the control group (P<0.05). After treatment,both groups showed a reduction in CRP,PCT,TNF-α,and IL-6 levels,but the study group had a more pronounced decrease (P<0.05). Similarly,while both groups experienced an improvement in FEV1,FVC,and PEF,the study group had a greater enhancement (P<0.05).Conclusion The combination of Feilike mixture and amoxicillin with clavulanate potassium for treating acute bronchitis in children yielded excellent results,markedly lowering serum inflammatory cytokine levels.
Amoxicillin and clavulanate potassiumFeilike mixtureAcute bronchitisInflammatory factor
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