Application Effect and Safety of Pulmonary Surfactant in Mechanical Ventilation Treatment of Neonatal Respiratory Distress Syndrome
Objective To observe the application effect and safety of pulmonary surfactant in the treatment of neonatal respiratory distress syndrome with mechanical ventilation.Methods A total of 68 children with neonatal respiratory distress syndrome diagnosed and treated in our hospital from January 2022 to September 2023 were selected as the research objects. They were divided into routine group and experimental group (n=34) by random number table method. The routine group was treated with mechanical ventilation,and the experimental group was treated with pulmonary surfactant on the basis of the routine group. The therapeutic effect,blood gas indexes[arterial partial pressure of oxygen (PaO2),arterial partial pressure of carbon dioxide (PaCO2),pH,inhaled oxygen concentration (PaO2/FiO2)],incidence of complications,mechanical ventilation time and hospitalization time were compared between the two groups.Results The total effective rate of treatment in the experimental group (97.06%) was higher than that in the routine group (85.29%) (P<0.05). After treatment,PaO2,pH and PaO2/FiO2 in the two groups were higher than those before treatment,PaCO2 was lower than that before treatment,and PaO2,pH and PaO2/FiO2 in the experimental group were higher than those in the routine group,PaCO2 was lower than that in the routine group (P<0.05). There was no significant difference in the incidence of complications between the experimental group and the routine group (P>0.05). The mechanical ventilation time and hospitalization time of the experimental group were shorter than those of the routine group (P<0.05).Conclusion Pulmonary surfactant and mechanical ventilation in the treatment of neonatal respiratory distress syndrome can achieve the ideal therapeutic effect,improve the total effective rate,improve blood gas treatment,promote ventilation improvement,shorten the treatment process,and have no significant complications,which is worthy of clinical application.