Accuracy of Dynamic Contrast-enhanced MRI in Predicting Pathological Complete Response After Neoadjuvant Chemotherapy for Breast Cancer
Objective To investigate the accuracy of dynamic contrast-enhanced MRI in predicting the pathological complete remission of breast cancer after neoadjuvant chemotherapy.Methods A total of 316 patients with breast cancer who were treated in our hospital from December 2018 to December 2021 were selected as the research objects. The results of radiation complete remission (rCR) and pathological complete remission (pCR) after neoadjuvant chemotherapy and surgical treatment were compared. The MRI parameters of true positive and false positive patients,true negative and false negative patients after neoadjuvant chemotherapy were compared. Results With the results of postoperative pathological examination of pCR as the gold standard,the sensitivity,specificity,accuracy,positive predictive value and negative predictive value of rCR in MRI were 81.82％,32.43％,70.25％,79.84％ and 35.29％,respectively,the Kappa value with pCR was 0.15. After neoadjuvant chemotherapy,there were significant differences in tumor diameter,background parenchymal enhancement and peritumoral edema between true positive and false positive patients(P<0.05). There were significant differences in breast tissue density and tumor edge enhancement between true negative and false negative patients ( P<0.05).Conclusion Dynamic contrast-enhanced MRI can be used as an important means to predict pCR after neoadjuvant chemotherapy for breast cancer. For indicators that affect the accuracy of prediction,sufficient attention needs to be paid in the work to further improve the accuracy of prediction.
Breast cancerNeoadjuvant chemotherapyPathological complete remissionPeritumor edema
万方数据
维普
