Clinical Efficacy of Shuganning Injection in the Treatment of Chronic Hepatitis B and its Effect on Liver Function Indexes
Objective To study the clinical efficacy of Shuganning injection in the treatment of chronic hepatitis B (CHB) and its effect on liver function.Methods A total of 60 patients with CHB admitted to Anyi County Hospital of Traditional Chinese Medicine from December 2020 to December 2022 were selected and divided into control group and observation group by random number table method,with 30 patients in each group. The control group was treated with conventional western medicine,and the observation group was treated with Shuganning injection on the basis of the control group. The clinical efficacy,liver function indexes[alanine aminotransferase (ALT),aspartate aminotransferase (AST),total bilirubin (TBIL),gamma-glutamyltransferase (GGT),total protein (ALP)],TCM symptom scores (abdominal distension pain,physical fatigue,skin yellow staining) and adverse reactions were compared between the two groups.Results The total effective rate of the observation group (96.67％) was higher than that of the control group (80.00％) (P<0.05). After treatment,the levels of ALT,AST,TBIL and GGT in the two groups were lower than those before treatment,ALP was higher than that before treatment,andthe levels of ALT,AST,TBIL and GGT in the observation group were lower than those in the control group,and ALP was higher than that in the control group (P<0.05). After treatment,the scores of TCM symptoms (abdominal distension pain,physical fatigue,yellow skin) in the two groups were lower than those before treatment,and the scores of TCM symptoms (abdominal distension pain,physical fatigue,yellow skin) in the observation group were lower than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion Shuganning injection is effective in the treatment of CHB,which can improve the clinical efficacy,improve the liver function of patients,reduce the symptoms of traditional Chinese medicine,and has high safety. It is worthy of application.
Chronic hepatitis BShuganningin jectionLiver functionTraditional Chinese medicine symptom score
万方数据
维普
