Clinical Efficacy and Safety of Azithromycin Combined with Feilike Mixture in the Treatment of Mycoplasma Pneumoniae Pneumonia
Objective To explore the clinical efficacy and safety of azithromycin combined with Feilike mixture in the treatment of mycoplasma pneumoniae pneumonia.Methods According to the random number table method,62 patients with mycoplasma pneumoniae pneumonia admitted to Jishui County People's Hospital from January 2021 to October 2023 were divided into control group(31 patients)and observation group(31 patients).The control group was treated with azithromycin,and the observation group was treated with Feilike mixture on the basis of the control group.The clinical efficacy,improvement time of symptoms(cough,fever,shortness of breath,chest pain,chest tightness,chills),lung function[maximum expiratory time,peak expiratory flow(PEF),maximum mid-expiratory flow(MMEF),maximum voluntary ventilation(MVV)percentage of predicted value(MVV%),forced vital capacity(FVC)percentage of predicted value(FVC%)],levels of inflammatory factors[C-reactive protein(CRP),interleukin-2(IL-2),interleukin-6(IL-16),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α)],incidence of adverse reactions(abdominal pain,diarrhea,nausea and vomiting,abnormal liver function,arrhythmia,allergy)were compared between the two groups.Results The observation group(96.77%)had higher the total effective rate than that of the control group(74.19%)(P＜0.05).The improvement time of cough,fever,shortness of breath,chest pain,chest tightness and chills in the observation group was shorter than that in the control group(P＜0.05).After treatment,the longest expiratory time,PEF,MMEF,MVV%and FVC%in the observation group were higher than those in the control group(P＜0.05).After treatment,the levels of CRP,IL-6,IL-10 and TNF-α in the observation group were lower than those in the control group,while the level of IL-2 was higher than that in the control group(P＜0.05).The incidence of adverse reactions in the observation group was 6.45%,which was lower than 25.81%in the control group(P＜0.05).Conclusion Azithromycin combined with Feilike mixture is effective in the treatment of mycoplasma pneumoniae pneumonia,which can promote the early outcome of symptoms,improve the lung function and inflammatory response of patients,and has high safety.
AzithromycinFeilike mixtureMycoplasma pneumoniae pneumoniaLung function
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