Objective To investigate the effect of invasive mechanical ventilation combined with high-flow oxygen therapy in the sequential treatment of type Ⅱrespiratory failure.Methods A total of 68 patients with type Ⅱ respiratory failure admitted to Yiyang County People's Hospital from June 2021 to October 2023 were selected as the research objects.According to the random number table method,they were divided into control group and study group,with 30 patients in each group.The control group was treated with invasive mechanical ventilation,and the study group was treated with invasive mechanical ventilation combined with high-flow oxygen therapy.The treatment effect,respiratory and circulatory indexes[partial pressure of oxygen(PaO2),partial pressure of carbon dioxide(PaCO2),oxygenation index(PaO2/FiO2),mean arterial pressure(MAP),heart rate(HR)],lung function indexes[forced vital capacity(FVC),maximum expiratory volume at 1 s after maximum inspiratory(FEV1),maximum expiratory flow rate(PEF)],inflammatory factor levels[nuclear transcription factor-κB(NF-κB),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)]were compared between the two groups.Results The total effective rate of the study group was higher than that of the control group(P＜0.05).The levels of PaO2 and PaO2/FiO2 in the study group were higher than those in the control group,and the levels of PaCO2,MAP and HR were lower than those in the control group(P＜0.05).The levels of FVC,FEV1 and PEF in the study group were higher than those in the control group(P＜0.05).The levels of IL-6,NF-κB and TNF-α in the study group were lower than those in the control group(P＜0.05).Conclusion Invasive mechanical ventilation combined with high-flow oxygen therapy is effective in the sequential treatment of type Ⅱ respiratory failure,which can improve the blood gas index,lung function index and inflammatory factor level of patients.
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