Objective To analyze the effect of knee arthroscopy combined with Shenxiao Plaster on knee joint function and postoperative pain in patients with osteoarthritis.Methods During February,2021 and February,2023,74 patients with osteoarthritis who were diagnosed and treated in our hospital were collected as the research objects,and they were randomly allocated into the control group and observation group by random number table method,each group contained 37 patients.In the control group,patients were treated knee arthroscopy,while patients in the observation group was added Shenxiao paster on the basis of the method which was carry out in the control group.The clinical efficacy,clinical symptoms(morning stiffness,joint swelling,tenderness)score,pain score(VAS),knee function score(Lysholm),osteoarthritis index(WOMAC)and the incidence of adverse reactions were compared between the control goup and the observation group.Results The observation group(94.59%)had higher the total effective rate than that in the control group(83.78%)(P<0.05).In terms of surgical outcomes,the observation group had lower scores of morning stiffness,joint swelling,tenderness,VAS,and WOMAC index,but had higher Lysholm score than that in the control group(P<0.05).The incidence of adverse reactions in the observation group was 8.11%,which was compared with 5.41%in the control group,the difference between the two groups was not statistically significant(P>0.05).Conclusion Knee arthroscopy combined with Shenxiao paste has a positive effect on knee joint function and postoperative pain in patients with osteoarthritis,which can reduce pain and clinical symptoms,improve knee joint function,reduce osteoarthritis index,and will not increase adverse reactions.It is worthy of clinical attention.