不同剂量瑞芬太尼用于无痛胃镜检查的有效性及安全性
Efficacy and Safety of Different Doses of Remifentanil for Painless Gastroscopy
李杨华1
作者信息
- 1. 婺源县人民医院麻醉科,江西 婺源 333200
- 折叠
摘要
目的 观察不同剂量瑞芬太尼用于无痛胃镜检查的有效性及安全性.方法 选取 2020 年 3 月-2023 年 3 月在我院进行无痛胃镜检查的 63 例患者为研究对象,采用随机数字表法分为A组、B组、C组,各组 21 例.A采用 0.1 μg/kg瑞芬太尼复合丙泊酚,B组采用 0.3 μg/kg瑞芬太尼复合丙泊酚,C组采用 0.6 μg/kg瑞芬太尼复合丙泊酚,比较三组麻醉效果、麻醉起效时间、定向力恢复时间、苏醒时间、生命体征[平均动脉压(MAP)、心率(HR)、血氧饱和度(SpO2)]、不耐受反应发生率、不良反应发生率.结果 B组、C组麻醉优良率均高于A组(P＜0.05),但B组和C组比较,差异无统计学意义(P＞0.05);C组、B组麻醉起效时间、定向力恢复时间、苏醒时间均短于A组(P＜0.05),但B组和C组比较,差异无统计学意义(P＞0.05);三组MAP、HR均低于给药前,且C组低于A组、B组(P＜0.05),A组和B组比较,差异无统计学意义(P＞0.05),三组给药前后SpO2 比较,差异无统计学意义(P＞0.05);C组不耐受反应发生率、不良反应发生率大于A组和B组(P＜0.05),但A组与B组比较,差异无统计学意义(P＞0.05).结论 不同剂量瑞芬太尼用于无痛胃镜检查有效性及安全性存在一定差异,但是相对而言,0.3 μg/kg瑞芬太尼不仅可实现良好的麻醉效果,而且可降低不良反应和不耐受发生率,维持生命体征相对稳定,保持良好的检查结束苏醒质量.
Abstract
Objective To observe the efficacy and safety of different doses of remifentanil for painless gastroscopy.Methods A total of 63 patients who underwent painless gastroscopy in our hospital from March 2020 to March 2023 were selected as the research objects.They were divided into group A,group B and group C by random number table method,with 21 patients in each group.The control group was treated with 0.1 μg/kg remifentanil combined with propofol,the group B was treated with 0.3 μg/kg remifentanil combined with propofol,and the group C was treated with 0.6 μg/kg remifentanil combined with propofol.The anesthetic effect,anesthesia onset time,orientation recovery time,recovery time,vital signs[mean arterial pressure(MAP),heart rate(HR),oxygen saturation(SpO2)],the incidence of intolerance and the incidence of adverse reactions were compared among the three groups.Results The excellent and good rate of anesthesia in group B and group C was higher than that in group A(P＜0.05),but there was no significant difference between group B and group C(P＞0.05).The onset time of anesthesia,recovery time of directional force and recovery time in group C and group B were shorter than those in group A(P＜0.05),but there was no significant difference between group B and group C(P＞0.05).The MAP and HR of the three groups were lower than those before administration,and those of the group C were lower than those of group A and group B(P＜0.05),but there were no significant difference between group A and group B(P＞0.05).There was no significant difference in SpO2 between the three groups before and after administration(P＞0.05).The incidence of intolerance and adverse reactions in group C was higher than that in group A and group B(P＜0.05),but there was no significant difference between group A and group B(P＞0.05).Conclusion There are some differences in the efficacy and safety of different doses of remifentanil for painless gastroscopy,but relatively speaking,0.3 μg/kg remifentanil can not only achieve good anesthetic effect,but also reduce the incidence of adverse reactions and intolerance,maintain relatively stable vital signs,and maintain good quality of recovery after examination.
关键词
不同剂量/瑞芬太尼/无痛胃镜检查/有效性/安全性Key words
Different doses/Remifentanil/Painless gastroscopy/Efficacy/Safety引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据