Value of Red Blood Cell Parameters in Differential Diagnosis of Thalassemia and Iron Deficiency Anemia
Objective To analyze the value of blood test red blood cell parameters in the differential diagnosis of thalassemia and iron deficiency anemia.Methods Patients with thalassemia(n=38)and iron deficiency anemia(n=38)diagnosed and treated in our hospital from January 2021 to September 2023 were selected as the research objects,and 38 healthy people who underwent physical examination in our hospital during the same period were selected as the control group.Blood routine tests were performed in each group.The mean corpuscular hemoglobin(MCH),hemoglobin(Hb),red blood cell count(RBC),mean red blood cell distribution width(RDW),mean corpuscular volume(MCV),serum iron(SI)and serum ferritin(SF)were compared among the three groups.The red blood cell parameters of patients with different types of thalassemia and iron deficiency anemia were tested,and the differential diagnostic efficacy of red blood cell parameters for thalassemia and iron deficiency anemia(sensitivity,specificity,accuracy,positive predictive value,negative predictive value)was analyzed.Results Hb,MCH and MCV in thalassemia group and iron deficiency anemia group were lower than those in control group,and RDW was higher than that in control group(P＜0.05).Hb,MCH and RBC in thalassemia group were higher than those in iron deficiency anemia group,while MCV and RDW in thalassemia group were lower than those in iron deficiency anemia group(P＜0.05).SF and SI in iron deficiency anemia group were lower than those in control group,SF in thalassemia group was higher than that in control group,and SF in iron deficiency anemia group was lower than that in thalassemia group(P＜0.05).RDW,RBC,MCV and MCH in iron deficiency anemia group were higher than those in α-thalassemia and β-thalassemia patients,and Hb was lower than that in α-thalassemia and β-thalassemia patients(P＜0.05).RBC and Hb in patients with α-thalassemia were lower than those in patients with β-thalassemia,MCV was higher than that in patients with β-thalassemia(P＜0.05),but RDW and MCH were not significantly different from those in patients with β-thalassemia(P＞0.05).There was no significant difference in the sensitivity,specificity,accuracy,positive predictive value and negative predictive value of red blood cell parameters in the diagnosis of thalassemia and iron deficiency anemia(P＞0.05).Conclusion There are differences in red blood cell parameters between patients with thalassemia and iron deficiency anemia,and some indexes of patients with different types of thalassemia are different.It has high diagnostic efficiency for the differential diagnosis of thalassemia and iron deficiency anemia,which is worthy of clinical attention.
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